Tag: CYP3A4 inhibition
Colchicine and Macrolides: How Common Antibiotics Can Trigger Deadly Toxicity
Dec 20, 2025 / 13 Comments
Colchicine is lifesaving for gout and heart conditions, but mixing it with common antibiotics like clarithromycin can cause deadly toxicity. Here's how CYP3A4 and P-gp inhibition creates the risk - and what to do about it.
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